Congratulations to our colleague MS Student. Le Ky Vien, for her recent publication entitled "Biogenic fluorescent carbon dot-decorated mesoporous organosilica nanoparticles for enhanced bioimaging and chemotherapy" in the journal " Nanoscale Horizons", which was a collaboration with our colleagues in the Center for INOMAR, VNU-HCM.
In this study, we report the green synthesis of fluorescent carbon dots (CDs) from banana (Musa paradisiaca cv. Awak) juice using a rapid microwave technique. These CDs are subsequently incorporated into biodegradable periodic mesoporous organosilica nanoparticles (BPMO) via the sol–gel method to form hybrid nanomaterials, BPMO@CDs. The hybrid materials exhibit high porosity, strong luminescence, low cytotoxicity, increased loading capacity, and enhanced toxicity toward cancer cells, demonstrating their potential for biomedical applications. For instance, we demonstrate that BPMO@CDs achieve efficient cellular uptake in MCF7 and L929 cells, with preserved fluorescence within the cells. The optical properties of the CDs are retained in the BPMO@CDs, allowing for detection upon cellular uptake. Additionally, when loaded with anticancer drugs, BPMO@CDs significantly enhance the cytotoxicity against MCF7 breast cancer cells, highlighting their potential for synergistic bioimaging and chemotherapy applications. This study provides a new concept of using environmentally friendly, biocompatible hybrid nanomaterials with potential for biomedical applications, particularly in bioimaging and drug delivery.
For more details, please visit:
https://doi.org/10.1039/D4NH00633J
Funding
This study was supported by the Vietnam National University, Ho Chi Minh City under grant number TX2025-50-01.
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